PDB 5ece

PDB Information

PDB5ECE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Johannes, J.W., Almeida, L., Daly, K., Ferguson, A.D., Grosskurth, S.E., Guan, H., Howard, T., Ioannidis, S., Kazmirski, S., Lamb, M.L., Larsen, N.A., Lyne, P.D., Mikule, K., Ogoe, C., Peng, B., Petteruti, P., Read, J.A., Su, N., Sylvester, M., Throner, S., Wang, W., Wang, X., Wu, J., Ye, Q., Yu, Y., Zheng, X., Scott, D.A.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-10-20
Resolution2.200
CATH Insert Date06 Dec, 2015

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 07 Dec, 2015 Chopped
B 07 Dec, 2015 Chopped
C 07 Dec, 2015 Chopped
D 07 Dec, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5eceA00 09 Dec, 2015 3.90.228.10 Assigned
5eceB00 05 Jan, 2016 3.90.228.10 Assigned
5eceC00 05 Jan, 2016 3.90.228.10 Assigned
5eceD00 05 Jan, 2016 3.90.228.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1