PDB 5e83

PDB Links
Overview

PDB Information

PDB	5E83
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Oksenberg, D., Dufu, K., Patel, M.P., Chuang, C., Li, Z., Xu, Q., Silva-Garcia, A., Zhou, C., Hutchaleelaha, A., Patskovska, L., Patskovsky, Y., Almo, S.C., Sinha, U., Metcalf, B.W., Archer, D.R. Br.J.Haematol.
Header	Oxygen Transport
Released	2015-10-13
Resolution	1.800
CATH Insert Date	24 Jul, 2016

PDB Images (9)

Image of CATH 5e83

5e83

PDB 5e83

Image of CATH 5e83A

5e83A

PDB Chain 5e83A

Image of CATH 5e83B

5e83B

PDB Chain 5e83B

Image of CATH 5e83C

5e83C

PDB Chain 5e83C

Image of CATH 5e83D

5e83D

PDB Chain 5e83D

Image of CATH 5e83A00

5e83A00

CATH Domain 5e83A00

Image of CATH 5e83B00

5e83B00

CATH Domain 5e83B00

Image of CATH 5e83C00

5e83C00

CATH Domain 5e83C00

Image of CATH 5e83D00

5e83D00

CATH Domain 5e83D00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	25 Jul, 2016	Chopped
B	25 Jul, 2016	Chopped
C	25 Jul, 2016	Chopped
D	25 Jul, 2016	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5e83A00	01 Sep, 2016	1.10.490.10	Assigned
5e83B00	01 Sep, 2016	1.10.490.10	Assigned
5e83C00	01 Sep, 2016	1.10.490.10	Assigned
5e83D00	01 Sep, 2016	1.10.490.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P69905	HBA_HUMAN	Homo sapiens	Hemoglobin subunit alpha
P68871	HBB_HUMAN	Homo sapiens	Hemoglobin subunit beta
P68871	HBB_HUMAN	Homo sapiens	Hemoglobin subunit beta
P69905	HBA_HUMAN	Homo sapiens	Hemoglobin subunit alpha