PDB 5cnk

PDB Information

PDB5CNK
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
Monn, J.A., Prieto, L., Taboada, L., Hao, J., Reinhard, M.R., Henry, S.S., Beadle, C.D., Walton, L., Man, T., Rudyk, H., Clark, B., Tupper, D., Baker, S.R., Lamas, C., Montero, C., Marcos, A., Blanco, J., Bures, M., Clawson, D.K., Atwell, S., Lu, F., Wang, J., Russell, M., Heinz, B.A., Wang, X., Carter, J.H., Getman, B.G., Catlow, J.T., Swanson, S., Johnson, B.G., Shaw, D.B., McKinzie, D.L.
J.Med.Chem.
HeaderSignaling Protein
Released2015-07-17
Resolution3.150
CATH Insert Date20 Sep, 2015

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped
C 21 Sep, 2015 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5cnkA01 30 Sep, 2015 3.40.50.2300 Assigned
5cnkA02 30 Sep, 2015 3.40.50.2300 Assigned
5cnkB01 30 Sep, 2015 3.40.50.2300 Assigned
5cnkB02 30 Sep, 2015 3.40.50.2300 Assigned
5cnkC01 30 Sep, 2015 3.40.50.2300 Assigned
5cnkC02 30 Sep, 2015 3.40.50.2300 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q14832 GRM3_HUMAN Homo sapiens Metabotropic glutamate receptor 3
Q14832 GRM3_HUMAN Homo sapiens Metabotropic glutamate receptor 3
Q14832 GRM3_HUMAN Homo sapiens Metabotropic glutamate receptor 3