PDB 5brz

PDB Information

PDB5BRZ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Raman, M.C., Rizkallah, P.J., Simmons, R., Donnellan, Z., Dukes, J., Bossi, G., Le Provost, G.S., Todorov, P., Baston, E., Hickman, E., Mahon, T., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Sci Rep
HeaderImmune System
Released2015-06-01
Resolution2.620
CATH Insert Date10 Apr, 2016

PDB Images (13)

PDB Prints

PDB Chains (5)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped
C 11 Apr, 2016 Rejected
D 11 Apr, 2016 Chopped
E 11 Apr, 2016 Chopped

CATH Domains (7)

Domain ID Date inserted into CATH Superfamily CATH Status
5brzA01 04 May, 2016 3.30.500.10 Assigned
5brzA02 04 May, 2016 2.60.40.10 Assigned
5brzB00 04 May, 2016 2.60.40.10 Assigned
5brzD01 04 May, 2016 2.60.40.10 Assigned
5brzD02 04 May, 2016 2.60.40.10 Assigned
5brzE01 04 May, 2016 2.60.40.10 Assigned
5brzE02 04 May, 2016 2.60.40.10 Assigned

UniProtKB Entries (7)

Accession Gene ID Taxon Description
A0A578 TVB51_HUMAN Homo sapiens T cell receptor beta variable 5-1
P43357 MAGA3_HUMAN Homo sapiens Melanoma-associated antigen 3
P61769 B2MG_HUMAN Homo sapiens Beta-2-microglobulin
A0A0B4J279 TVA21_HUMAN Homo sapiens T cell receptor alpha variable 21
P01848 TRAC_HUMAN Homo sapiens T cell receptor alpha constant
A0A5B9 TRBC2_HUMAN Homo sapiens T cell receptor beta constant 2
P30443 1A01_HUMAN Homo sapiens HLA class I histocompatibility antigen, A-1 alpha chain