PDB 4ztm

PDB Information

PDB4ZTM
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
Seganish, W.M., Fischmann, T.O., Sherborne, B., Matasi, J., Lavey, B., McElroy, W.T., Tulshian, D., Tata, J., Sondey, C., Garlisi, C.G., Devito, K., Fossetta, J., Lundell, D., Niu, X.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-05-14
Resolution2.660
CATH Insert Date20 Sep, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped
C 21 Sep, 2015 Chopped
D 21 Sep, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4ztmA01 30 Sep, 2015 3.30.200.20 Assigned
4ztmA02 30 Sep, 2015 1.10.510.10 Assigned
4ztmB01 30 Sep, 2015 3.30.200.20 Assigned
4ztmB02 30 Sep, 2015 1.10.510.10 Assigned
4ztmC01 30 Sep, 2015 3.30.200.20 Assigned
4ztmC02 30 Sep, 2015 1.10.510.10 Assigned
4ztmD01 30 Sep, 2015 3.30.200.20 Assigned
4ztmD02 30 Sep, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4