PDB 4ztl

PDB Information

PDB4ZTL
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
Seganish, W.M., Fischmann, T.O., Sherborne, B., Matasi, J., Lavey, B., McElroy, W.T., Tulshian, D., Tata, J., Sondey, C., Garlisi, C.G., Devito, K., Fossetta, J., Lundell, D., Niu, X.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-05-14
Resolution2.390
CATH Insert Date20 Sep, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped
C 21 Sep, 2015 Chopped
D 21 Sep, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4ztlA01 30 Sep, 2015 3.30.200.20 Assigned
4ztlA02 30 Sep, 2015 1.10.510.10 Assigned
4ztlB01 30 Sep, 2015 3.30.200.20 Assigned
4ztlB02 30 Sep, 2015 1.10.510.10 Assigned
4ztlC01 30 Sep, 2015 3.30.200.20 Assigned
4ztlC02 30 Sep, 2015 1.10.510.10 Assigned
4ztlD01 30 Sep, 2015 3.30.200.20 Assigned
4ztlD02 30 Sep, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4