PDB 4zgx

PDB Information

PDB4ZGX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Martin, R.E., Aebi, J.D., Hornsperger, B., Krebs, H.J., Kuhn, B., Kuglstatter, A., Alker, A.M., Marki, H.P., Muller, S., Burger, D., Ottaviani, G., Riboulet, W., Verry, P., Tan, X., Amrein, K., Mayweg, A.V.
J.Med.Chem.
HeaderOxidoreductase
Released2015-04-24
Resolution3.200
CATH Insert Date18 Oct, 2015

PDB Images (25)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 19 Oct, 2015 Chopped
B 19 Oct, 2015 Chopped
C 19 Oct, 2015 Chopped
D 19 Oct, 2015 Chopped
E 19 Oct, 2015 Chopped
F 19 Oct, 2015 Chopped
G 19 Oct, 2015 Chopped
H 19 Oct, 2015 Chopped
I 19 Oct, 2015 Chopped
J 19 Oct, 2015 Chopped
K 19 Oct, 2015 Chopped
L 19 Oct, 2015 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
4zgxA00 01 Nov, 2015 1.10.630.10 Assigned
4zgxB00 01 Nov, 2015 1.10.630.10 Assigned
4zgxC00 01 Nov, 2015 1.10.630.10 Assigned
4zgxD00 01 Nov, 2015 1.10.630.10 Assigned
4zgxE00 01 Nov, 2015 1.10.630.10 Assigned
4zgxF00 31 Oct, 2015 1.10.630.10 Assigned
4zgxG00 01 Nov, 2015 1.10.630.10 Assigned
4zgxH00 01 Nov, 2015 1.10.630.10 Assigned
4zgxI00 01 Nov, 2015 1.10.630.10 Assigned
4zgxJ00 01 Nov, 2015 1.10.630.10 Assigned
4zgxK00 01 Nov, 2015 1.10.630.10 Assigned
4zgxL00 01 Nov, 2015 1.10.630.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial
P19099 C11B2_HUMAN Homo sapiens Cytochrome P450 11B2, mitochondrial