PDB 4z1s

PDB Information

PDB4Z1S
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
Taylor, A.M., Vaswani, R.G., Gehling, V.S., Hewitt, M.C., Leblanc, Y., Audia, J.E., Bellon, S., Cummings, R.T., Cote, A., Harmange, J.C., Jayaram, H., Joshi, S., Lora, J.M., Mertz, J.A., Neiss, A., Pardo, E., Nasveschuk, C.G., Poy, F., Sandy, P., Setser, J.W., Sims, R.J., Tang, Y., Albrecht, B.K.
Acs Med.Chem.Lett.
HeaderSignaling Protein
Released2015-03-27
Resolution1.060
CATH Insert Date28 Jun, 2015

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4z1sA01 27 Jul, 2015 1.20.920.10 Assigned
4z1sB01 27 Jul, 2015 1.20.920.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O60885 BRD4_HUMAN Homo sapiens Bromodomain-containing protein 4
O60885 BRD4_HUMAN Homo sapiens Bromodomain-containing protein 4