PDB 4ybi

PDB Information

PDB4YBI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
May, P.C., Dean, R.A., Lowe, S.L., Martenyi, F., Sheehan, S.M., Boggs, L.N., Monk, S.A., Mathes, B.M., Mergott, D.J., Watson, B.M., Stout, S.L., Timm, D.E., Smith Labell, E., Gonzales, C.R., Nakano, M., Jhee, S.S., Yen, M., Ereshefsky, L., Lindstrom, T.D., Calligaro, D.O., Cocke, P.J., Greg Hall, D., Friedrich, S., Citron, M., Audia, J.E.
J.Neurosci.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-02-18
Resolution1.840
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4ybiA01 22 Jul, 2015 2.40.70.10 Assigned
4ybiA02 22 Jul, 2015 2.40.70.10 Assigned
4ybiB01 22 Jul, 2015 2.40.70.10 Assigned
4ybiB02 22 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1