PDB 4y8x

PDB Information

PDB4Y8X
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.
Hu, Z., Wong, P.C., Gilligan, P.J., Han, W., Pabbisetty, K.B., Bozarth, J.M., Crain, E.J., Harper, T., Luettgen, J.M., Myers, J.E., Ramamurthy, V., Rossi, K.A., Sheriff, S., Watson, C.A., Wei, A., Zheng, J.J., Seiffert, D.A., Wexler, R.R., Quan, M.L.
ACS Med Chem Lett
HeaderHydrolase/Hydrolase Inhibitor
Released2015-02-16
Resolution1.900
CATH Insert Date28 Jun, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4y8xA01 22 Jul, 2015 2.40.10.10 Assigned
4y8xA02 22 Jul, 2015 2.40.10.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P03951 FA11_HUMAN Homo sapiens Coagulation factor XI
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