PDB 4wwo

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Overview

PDB Information

PDB	4WWO
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. Cushing, T.D., Hao, X., Shin, Y., Andrews, K., Brown, M., Cardozo, M., Chen, Y., Duquette, J., Fisher, B., Gonzalez-Lopez de Turiso, F., He, X., Henne, K.R., Hu, Y.L., Hungate, R., Johnson, M.G., Kelly, R.C., Lucas, B., McCarter, J.D., McGee, L.R., Medina, J.C., San Miguel, T., Mohn, D., Pattaropong, V., Pettus, L.H., Reichelt, A., Rzasa, R.M., Seganish, J., Tasker, A.S., Wahl, R.C., Wannberg, S., Whittington, D.A., Whoriskey, J., Yu, G., Zalameda, L., Zhang, D., Metz, D.P. J.Med.Chem.
Header	Transferase/Transferase Inhibitor
Released	2014-11-11
Resolution	2.300
CATH Insert Date	28 Dec, 2014

PDB Images (7)

Image of CATH 4wwo

4wwo

PDB 4wwo

Image of CATH 4wwoA

4wwoA

PDB Chain 4wwoA

Image of CATH 4wwoA01

4wwoA01

CATH Domain 4wwoA01

Image of CATH 4wwoA02

4wwoA02

CATH Domain 4wwoA02

Image of CATH 4wwoA03

4wwoA03

CATH Domain 4wwoA03

Image of CATH 4wwoA04

4wwoA04

CATH Domain 4wwoA04

Image of CATH 4wwoA05

4wwoA05

CATH Domain 4wwoA05

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	29 Dec, 2014	Chopped

CATH Domains (5)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4wwoA01	05 Jan, 2015	3.10.20.90	Assigned
4wwoA02	05 Jan, 2015	2.60.40.150	Assigned
4wwoA03	05 Jan, 2015	1.25.40.70	Assigned
4wwoA04	05 Jan, 2015	3.30.1010.10	Assigned
4wwoA05	05 Jan, 2015	1.10.1070.11	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P48736	PK3CG_HUMAN	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform