PDB 4wn1

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Overview

PDB Information

PDB	4WN1
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition. Hamaguchi, W., Masuda, N., Miyamoto, S., Shiina, Y., Kikuchi, S., Mihara, T., Moriguchi, H., Fushiki, H., Murakami, Y., Amano, Y., Honbou, K., Hattori, K. Bioorg.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-10-10
Resolution	3.130
CATH Insert Date	04 Jan, 2015

PDB Images (5)

Image of CATH 4wn1

4wn1

PDB 4wn1

Image of CATH 4wn1A

4wn1A

PDB Chain 4wn1A

Image of CATH 4wn1B

4wn1B

PDB Chain 4wn1B

Image of CATH 4wn1A00

4wn1A00

CATH Domain 4wn1A00

Image of CATH 4wn1B00

4wn1B00

CATH Domain 4wn1B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	05 Jan, 2015	Chopped
B	05 Jan, 2015	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4wn1A00	08 Jan, 2015	1.10.1300.10	Assigned
4wn1B00	10 Jan, 2015	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A