PDB 4w9j

PDB Information

PDB4W9J
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderTranscription
Released2014-08-27
Resolution2.200
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9jA00 17 Sep, 2014 3.10.20.90 Assigned
4w9jB00 17 Sep, 2014 3.30.710.10 Assigned
4w9jC01 17 Sep, 2014 2.60.40.780 Assigned
4w9jC02 17 Sep, 2014 1.10.750.10 Assigned
4w9jD00 17 Sep, 2014 3.10.20.90 Assigned
4w9jE00 17 Sep, 2014 3.30.710.10 Assigned
4w9jF01 17 Sep, 2014 2.60.40.780 Assigned
4w9jF02 17 Sep, 2014 1.10.750.10 Assigned
4w9jG00 17 Sep, 2014 3.10.20.90 Assigned
4w9jH00 17 Sep, 2014 3.30.710.10 Assigned
4w9jI01 17 Sep, 2014 2.60.40.780 Assigned
4w9jI02 17 Sep, 2014 1.10.750.10 Assigned
4w9jJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9jK00 17 Sep, 2014 3.30.710.10 Assigned
4w9jL01 17 Sep, 2014 2.60.40.780 Assigned
4w9jL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B