PDB 4w9h

PDB Information

PDB4W9H
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.100
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9hA00 17 Sep, 2014 3.10.20.90 Assigned
4w9hB00 17 Sep, 2014 3.30.710.10 Assigned
4w9hC01 17 Sep, 2014 2.60.40.780 Assigned
4w9hC02 17 Sep, 2014 1.10.750.10 Assigned
4w9hD00 17 Sep, 2014 3.10.20.90 Assigned
4w9hE00 17 Sep, 2014 3.30.710.10 Assigned
4w9hF01 17 Sep, 2014 2.60.40.780 Assigned
4w9hF02 17 Sep, 2014 1.10.750.10 Assigned
4w9hG00 17 Sep, 2014 3.10.20.90 Assigned
4w9hH00 17 Sep, 2014 3.30.710.10 Assigned
4w9hI01 17 Sep, 2014 2.60.40.780 Assigned
4w9hI02 17 Sep, 2014 1.10.750.10 Assigned
4w9hJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9hK00 17 Sep, 2014 3.30.710.10 Assigned
4w9hL01 17 Sep, 2014 2.60.40.780 Assigned
4w9hL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B