PDB 4w9g

PDB Information

PDB4W9G
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.700
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9gA00 17 Sep, 2014 3.10.20.90 Assigned
4w9gB00 17 Sep, 2014 3.30.710.10 Assigned
4w9gC01 17 Sep, 2014 2.60.40.780 Assigned
4w9gC02 17 Sep, 2014 1.10.750.10 Assigned
4w9gD00 17 Sep, 2014 3.10.20.90 Assigned
4w9gE00 17 Sep, 2014 3.30.710.10 Assigned
4w9gF01 17 Sep, 2014 2.60.40.780 Assigned
4w9gF02 17 Sep, 2014 1.10.750.10 Assigned
4w9gG00 17 Sep, 2014 3.10.20.90 Assigned
4w9gH00 17 Sep, 2014 3.30.710.10 Assigned
4w9gI01 17 Sep, 2014 2.60.40.780 Assigned
4w9gI02 17 Sep, 2014 1.10.750.10 Assigned
4w9gJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9gK00 17 Sep, 2014 3.30.710.10 Assigned
4w9gL01 17 Sep, 2014 2.60.40.780 Assigned
4w9gL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B