PDB 4w9f

PDB Information

PDB4W9F
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.100
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9fA00 16 Sep, 2014 3.10.20.90 Assigned
4w9fB00 16 Sep, 2014 3.30.710.10 Assigned
4w9fC01 16 Sep, 2014 2.60.40.780 Assigned
4w9fC02 16 Sep, 2014 1.10.750.10 Assigned
4w9fD00 16 Sep, 2014 3.10.20.90 Assigned
4w9fE00 16 Sep, 2014 3.30.710.10 Assigned
4w9fF01 16 Sep, 2014 2.60.40.780 Assigned
4w9fF02 16 Sep, 2014 1.10.750.10 Assigned
4w9fG00 16 Sep, 2014 3.10.20.90 Assigned
4w9fH00 16 Sep, 2014 3.30.710.10 Assigned
4w9fI01 16 Sep, 2014 2.60.40.780 Assigned
4w9fI02 16 Sep, 2014 1.10.750.10 Assigned
4w9fJ00 16 Sep, 2014 3.10.20.90 Assigned
4w9fK00 16 Sep, 2014 3.30.710.10 Assigned
4w9fL01 16 Sep, 2014 2.60.40.780 Assigned
4w9fL02 16 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor