PDB 4w9d

PDB Information

PDB4W9D
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.200
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9dA00 17 Sep, 2014 3.10.20.90 Assigned
4w9dB00 17 Sep, 2014 3.30.710.10 Assigned
4w9dC01 17 Sep, 2014 2.60.40.780 Assigned
4w9dC02 17 Sep, 2014 1.10.750.10 Assigned
4w9dD00 17 Sep, 2014 3.10.20.90 Assigned
4w9dE00 17 Sep, 2014 3.30.710.10 Assigned
4w9dF01 17 Sep, 2014 2.60.40.780 Assigned
4w9dF02 17 Sep, 2014 1.10.750.10 Assigned
4w9dG00 17 Sep, 2014 3.10.20.90 Assigned
4w9dH00 17 Sep, 2014 3.30.710.10 Assigned
4w9dI01 17 Sep, 2014 2.60.40.780 Assigned
4w9dI02 17 Sep, 2014 1.10.750.10 Assigned
4w9dJ00 16 Sep, 2014 3.10.20.90 Assigned
4w9dK00 16 Sep, 2014 3.30.710.10 Assigned
4w9dL01 16 Sep, 2014 2.60.40.780 Assigned
4w9dL02 16 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor