PDB 4w9c

PDB Information

PDB4W9C
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.200
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9cA00 17 Sep, 2014 3.10.20.90 Assigned
4w9cB00 17 Sep, 2014 3.30.710.10 Assigned
4w9cC01 17 Sep, 2014 2.60.40.780 Assigned
4w9cC02 17 Sep, 2014 1.10.750.10 Assigned
4w9cD00 17 Sep, 2014 3.10.20.90 Assigned
4w9cE00 17 Sep, 2014 3.30.710.10 Assigned
4w9cF01 16 Sep, 2014 2.60.40.780 Assigned
4w9cF02 16 Sep, 2014 1.10.750.10 Assigned
4w9cG00 16 Sep, 2014 3.10.20.90 Assigned
4w9cH00 16 Sep, 2014 3.30.710.10 Assigned
4w9cI01 17 Sep, 2014 2.60.40.780 Assigned
4w9cI02 17 Sep, 2014 1.10.750.10 Assigned
4w9cJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9cK00 17 Sep, 2014 3.30.710.10 Assigned
4w9cL01 17 Sep, 2014 2.60.40.780 Assigned
4w9cL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor