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PDB 4v25

PDB Information

PDB4V25
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.
Moore, J.D., Staniszewska, A., Shaw, T., D'Alessandro, J., Davis, B., Surgenor, A., Baker, L., Matassova, N., Murray, J., Macias, A., Brough, P., Wood, M., Mahon, P.C.
Oncotarget
HeaderTransferase
Released2014-10-06
Resolution2.600
CATH Insert Date14 Dec, 2014

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 15 Dec, 2014 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4v25A01 28 Dec, 2014 1.20.140.20 Assigned
4v25A02 28 Dec, 2014 3.30.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q15119 PDK2_HUMAN Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
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