PDB Information

PDB4UWK
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil-Sizaire, C., Fassy, F., Abecassis, P., Mathieu, M., Bertrand, T., Benard, T., Barriere, C., El Batti, S., Letallec, J., Sonnefraud, V., Brollo, M., Delbarre, L., Loyau, V., Pilorge, F., Bertin, L., Richepin, P., Arigon, J., Labrosse, J., Clement, J., Durand, F., Combet, R., Perraut, P., Leroy, V., Gay, F., Lefrancois, D., Bretin, F., Marquette, J., Michot, N., Caron, A., Castell, C., Schio, L., Mccort, G., Goulaouic, H., Garcia-Echeverria, C., Ronan, B.P.
J.Med.Chem.
HeaderTransferase
Released2014-08-12
Resolution2.830
CATH Insert Date07 Dec, 2014

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Dec, 2014 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4uwkA01 29 Dec, 2014 1.25.40.70 Assigned
4uwkA02 29 Dec, 2014 3.30.1010.10 Assigned
4uwkA03 29 Dec, 2014 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q8NEB9 PK3C3_HUMAN Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3