PDB 4uw1

PDB Information

PDB4UW1
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
Elliot, R.J., Jarvis, A., Rajasekaran, M.B., Menon, M., Bowers, L., Boffey, R., Bayford, M., Firth-Clark, S., Beevers, R., Aquil, R., Kirton, S.B., Niculescu-Duvaz, D., Fish, L., Lopes, F., Mcleary, R., Trindade, I., Vendrell, E., Munkonge, F., Porter, R., Perrior, T., Springer, C., Oliver, A.W., Pearl, L.H., Ashworth, A., Lord, C.J.
Medchemcommm
HeaderTransferase
Released2014-08-08
Resolution3.370
CATH Insert Date16 Aug, 2015

PDB Images (17)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 17 Aug, 2015 Chopped
B 17 Aug, 2015 Chopped
C 17 Aug, 2015 Chopped
D 17 Aug, 2015 Chopped
E 17 Aug, 2015 Chopped
F 17 Aug, 2015 Chopped
G 17 Aug, 2015 Chopped
H 17 Aug, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4uw1A00 24 Aug, 2015 3.90.228.10 Assigned
4uw1B00 24 Aug, 2015 3.90.228.10 Assigned
4uw1C00 24 Aug, 2015 3.90.228.10 Assigned
4uw1D00 24 Aug, 2015 3.90.228.10 Assigned
4uw1E00 24 Aug, 2015 3.90.228.10 Assigned
4uw1F00 24 Aug, 2015 3.90.228.10 Assigned
4uw1G00 24 Aug, 2015 3.90.228.10 Assigned
4uw1H00 24 Aug, 2015 3.90.228.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1