PDB 4tpp

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Overview

PDB Information

PDB	4TPP
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Rzasa, R.M., Frohn, M.J., Andrews, K.L., Chmait, S., Chen, N., Clarine, J.G., Davis, C., Eastwood, H.A., Horne, D.B., Hu, E., Jones, A.D., Kaller, M.R., Kunz, R.K., Miller, S., Monenschein, H., Nguyen, T., Pickrell, A.J., Porter, A., Reichelt, A., Zhao, X., Treanor, J.J., Allen, J.R. Bioorg.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-06-09
Resolution	2.650
CATH Insert Date	28 Dec, 2014

PDB Images (5)

Image of CATH 4tpp

4tpp

PDB 4tpp

Image of CATH 4tppA

4tppA

PDB Chain 4tppA

Image of CATH 4tppB

4tppB

PDB Chain 4tppB

Image of CATH 4tppA00

4tppA00

CATH Domain 4tppA00

Image of CATH 4tppB00

4tppB00

CATH Domain 4tppB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	29 Dec, 2014	Chopped
B	29 Dec, 2014	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4tppA00	06 Jan, 2015	1.10.1300.10	Assigned
4tppB00	06 Jan, 2015	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A