PDB 4tpm

PDB Information

PDB4TPM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Rzasa, R.M., Frohn, M.J., Andrews, K.L., Chmait, S., Chen, N., Clarine, J.G., Davis, C., Eastwood, H.A., Horne, D.B., Hu, E., Jones, A.D., Kaller, M.R., Kunz, R.K., Miller, S., Monenschein, H., Nguyen, T., Pickrell, A.J., Porter, A., Reichelt, A., Zhao, X., Treanor, J.J., Allen, J.R.
Bioorg.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-06-08
Resolution2.770
CATH Insert Date28 Dec, 2014

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Dec, 2014 Chopped
B 29 Dec, 2014 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4tpmA00 06 Jan, 2015 1.10.1300.10 Assigned
4tpmB00 05 Jan, 2015 1.10.1300.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A