PDB 4tot

PDB Information

PDB4TOT
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Fu, J., Tjandra, M., Becker, C., Bednarczyk, D., Capparelli, M., Elling, R., Hanna, I., Fujimoto, R., Furegati, M., Karur, S., Kasprzyk, T., Knapp, M., Leung, K., Li, X., Lu, P., Mergo, W., Miault, C., Ng, S., Parker, D., Peng, Y., Roggo, S., Rivkin, A., Simmons, R.L., Wang, M., Wiedmann, B., Weiss, A.H., Xiao, L., Xie, L., Xu, W., Yifru, A., Yang, S., Zhou, B., Sweeney, Z.K.
J.Med.Chem.
HeaderIsomerase/Isomerase Inhibitor
Released2014-06-06
Resolution2.390
CATH Insert Date30 Nov, 2014

PDB Images (13)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 01 Dec, 2014 Chopped
B 01 Dec, 2014 Chopped
C 01 Dec, 2014 Chopped
D 01 Dec, 2014 Chopped
E 01 Dec, 2014 Rejected
F 01 Dec, 2014 Rejected
G 01 Dec, 2014 Rejected
H 01 Dec, 2014 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4totA00 02 Dec, 2014 2.40.100.10 Assigned
4totB00 03 Dec, 2014 2.40.100.10 Assigned
4totC00 03 Dec, 2014 2.40.100.10 Assigned
4totD00 03 Dec, 2014 2.40.100.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P29117 PPIF_RAT Rattus norvegicus Peptidyl-prolyl cis-trans isomerase F, mitochondrial
P29117 PPIF_RAT Rattus norvegicus Peptidyl-prolyl cis-trans isomerase F, mitochondrial
P29117 PPIF_RAT Rattus norvegicus Peptidyl-prolyl cis-trans isomerase F, mitochondrial
P29117 PPIF_RAT Rattus norvegicus Peptidyl-prolyl cis-trans isomerase F, mitochondrial
CATH-Gene3D is a Global Biodata Core Resource Learn more...