PDB 4rio

PDB Information

PDB4RIO
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Duan, J.J., Lu, Z., Jiang, B., Yang, B.V., Doweyko, L.M., Nirschl, D.S., Haque, L.E., Lin, S., Brown, G., Hynes, J., Tokarski, J.S., Sack, J.S., Khan, J., Lippy, J.S., Zhang, R.F., Pitt, S., Shen, G., Pitts, W.J., Carter, P.H., Barrish, J.C., Nadler, S.G., Salter-Cid, L.M., McKinnon, M., Fura, A., Schieven, G.L., Wrobleski, S.T.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Inhibitor
Released2014-10-07
Resolution2.690
CATH Insert Date04 Jan, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Jan, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4rioA01 08 Jan, 2015 3.30.200.20 Assigned
4rioA02 08 Jan, 2015 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3