PDB Information

PDB4R92
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent iminoheterocycle BACE1 inhibitors.
Caldwell, J.P., Mazzola, R.D., Durkin, J., Chen, J., Chen, X., Favreau, L., Kennedy, M., Kuvelkar, R., Lee, J., McHugh, N., McKittrick, B., Orth, P., Stamford, A., Strickland, C., Voigt, J., Wang, L., Zhang, L., Zhang, Q., Zhu, Z.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-09-03
Resolution1.710
CATH Insert Date16 Nov, 2014

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 17 Nov, 2014 Chopped
B 17 Nov, 2014 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4r92A01 19 Nov, 2014 2.40.70.10 Assigned
4r92A02 19 Nov, 2014 2.40.70.10 Assigned
4r92B01 19 Nov, 2014 2.40.70.10 Assigned
4r92B02 19 Nov, 2014 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1