PDB 4r68

PDB Information

PDB4R68
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Labadie, S., Dragovich, P.S., Chen, J., Fauber, B.P., Boggs, J., Corson, L.B., Ding, C.Z., Eigenbrot, C., Ge, H., Ho, Q., Lai, K.W., Ma, S., Malek, S., Peterson, D., Purkey, H.E., Robarge, K., Salphati, L., Sideris, S., Ultsch, M., VanderPorten, E., Wei, B., Xu, Q., Yen, I., Yue, Q., Zhang, H., Zhang, X., Zhou, A.
Bioorg.Med.Chem.Lett.
HeaderOxidoreductase
Released2014-08-22
Resolution2.110
CATH Insert Date04 Jan, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Jan, 2015 Chopped
B 05 Jan, 2015 Chopped
C 05 Jan, 2015 Chopped
D 05 Jan, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4r68A01 10 Jan, 2015 3.40.50.720 Assigned
4r68A02 10 Jan, 2015 3.90.110.10 Assigned
4r68B01 10 Jan, 2015 3.40.50.720 Assigned
4r68B02 10 Jan, 2015 3.90.110.10 Assigned
4r68C01 10 Jan, 2015 3.40.50.720 Assigned
4r68C02 10 Jan, 2015 3.90.110.10 Assigned
4r68D01 10 Jan, 2015 3.40.50.720 Assigned
4r68D02 10 Jan, 2015 3.90.110.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain