PDB 4r67

PDB Links
Overview

PDB Information

PDB	4R67
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib. Harshbarger, W., Miller, C., Diedrich, C., Sacchettini, J. Structure
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-08-22
Resolution	2.890
CATH Insert Date	28 Jun, 2015

PDB Images (113)

4r67

PDB 4r67

4r670

PDB Chain 4r670

4r671

PDB Chain 4r671

4r672

PDB Chain 4r672

4r673

PDB Chain 4r673

4r67a

PDB Chain 4r67a

4r67A

PDB Chain 4r67A

4r67b

PDB Chain 4r67b

4r67B

PDB Chain 4r67B

4r67c

PDB Chain 4r67c

4r67C

PDB Chain 4r67C

4r67d

PDB Chain 4r67d

4r67D

PDB Chain 4r67D

4r67e

PDB Chain 4r67e

4r67E

PDB Chain 4r67E

4r67f

PDB Chain 4r67f

4r67F

PDB Chain 4r67F

4r67g

PDB Chain 4r67g

4r67G

PDB Chain 4r67G

4r67h

PDB Chain 4r67h

4r67H

PDB Chain 4r67H

4r67i

PDB Chain 4r67i

4r67I

PDB Chain 4r67I

4r67j

PDB Chain 4r67j

4r67J

PDB Chain 4r67J

4r67k

PDB Chain 4r67k

4r67K

PDB Chain 4r67K

4r67l

PDB Chain 4r67l

4r67L

PDB Chain 4r67L

4r67m

PDB Chain 4r67m

4r67M

PDB Chain 4r67M

4r67n

PDB Chain 4r67n

4r67N

PDB Chain 4r67N

4r67o

PDB Chain 4r67o

4r67O

PDB Chain 4r67O

4r67p

PDB Chain 4r67p

4r67P

PDB Chain 4r67P

4r67q

PDB Chain 4r67q

4r67Q

PDB Chain 4r67Q

4r67r

PDB Chain 4r67r

4r67R

PDB Chain 4r67R

4r67s

PDB Chain 4r67s

4r67S

PDB Chain 4r67S

4r67t

PDB Chain 4r67t

4r67T

PDB Chain 4r67T

4r67u

PDB Chain 4r67u

4r67U

PDB Chain 4r67U

4r67v

PDB Chain 4r67v

4r67V

PDB Chain 4r67V

4r67w

PDB Chain 4r67w

4r67W

PDB Chain 4r67W

4r67x

PDB Chain 4r67x

4r67X

PDB Chain 4r67X

4r67y

PDB Chain 4r67y

4r67Y

PDB Chain 4r67Y

4r67z

PDB Chain 4r67z

4r67Z

PDB Chain 4r67Z

4r67000

CATH Domain 4r67000

4r67100

CATH Domain 4r67100

4r67200

CATH Domain 4r67200

4r67300

CATH Domain 4r67300

4r67a00

CATH Domain 4r67a00

4r67A00

CATH Domain 4r67A00

4r67b00

CATH Domain 4r67b00

4r67B00

CATH Domain 4r67B00

4r67c00

CATH Domain 4r67c00

4r67C00

CATH Domain 4r67C00

4r67d00

CATH Domain 4r67d00

4r67D00

CATH Domain 4r67D00

4r67e00

CATH Domain 4r67e00

4r67E00

CATH Domain 4r67E00

4r67f00

CATH Domain 4r67f00

4r67F00

CATH Domain 4r67F00

4r67g00

CATH Domain 4r67g00

4r67G00

CATH Domain 4r67G00

4r67h00

CATH Domain 4r67h00

4r67H00

CATH Domain 4r67H00

4r67i00

CATH Domain 4r67i00

4r67I00

CATH Domain 4r67I00

4r67j00

CATH Domain 4r67j00

4r67J00

CATH Domain 4r67J00

4r67k00

CATH Domain 4r67k00

4r67K00

CATH Domain 4r67K00

4r67l00

CATH Domain 4r67l00

4r67L00

CATH Domain 4r67L00

4r67m00

CATH Domain 4r67m00

4r67M00

CATH Domain 4r67M00

4r67n00

CATH Domain 4r67n00

4r67N00

CATH Domain 4r67N00

4r67o00

CATH Domain 4r67o00

4r67O00

CATH Domain 4r67O00

4r67p00

CATH Domain 4r67p00

4r67P00

CATH Domain 4r67P00

4r67q00

CATH Domain 4r67q00

4r67Q00

CATH Domain 4r67Q00

4r67r00

CATH Domain 4r67r00

4r67R00

CATH Domain 4r67R00

4r67s00

CATH Domain 4r67s00

4r67S00

CATH Domain 4r67S00

4r67t00

CATH Domain 4r67t00

4r67T00

CATH Domain 4r67T00

4r67u00

CATH Domain 4r67u00

4r67U00

CATH Domain 4r67U00

4r67v00

CATH Domain 4r67v00

4r67V00

CATH Domain 4r67V00

4r67w00

CATH Domain 4r67w00

4r67W00

CATH Domain 4r67W00

4r67x00

CATH Domain 4r67x00

4r67X00

CATH Domain 4r67X00

4r67y00

CATH Domain 4r67y00

4r67Y00

CATH Domain 4r67Y00

4r67z00

CATH Domain 4r67z00

4r67Z00

CATH Domain 4r67Z00

PDB Prints

PDB Chains (56)

Chain ID	Date inserted into CATH	CATH Status
0	29 Jun, 2015	Chopped
1	29 Jun, 2015	Chopped
2	29 Jun, 2015	Chopped
3	29 Jun, 2015	Chopped
a	29 Jun, 2015	Chopped
A	29 Jun, 2015	Chopped
b	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped
c	29 Jun, 2015	Chopped
C	29 Jun, 2015	Chopped
d	29 Jun, 2015	Chopped
D	29 Jun, 2015	Chopped
e	29 Jun, 2015	Chopped
E	29 Jun, 2015	Chopped
f	29 Jun, 2015	Chopped
F	29 Jun, 2015	Chopped
g	29 Jun, 2015	Chopped
G	29 Jun, 2015	Chopped
h	29 Jun, 2015	Chopped
H	29 Jun, 2015	Chopped
i	29 Jun, 2015	Chopped
I	29 Jun, 2015	Chopped
j	29 Jun, 2015	Chopped
J	29 Jun, 2015	Chopped
k	29 Jun, 2015	Chopped
K	29 Jun, 2015	Chopped
l	29 Jun, 2015	Chopped
L	29 Jun, 2015	Chopped
m	29 Jun, 2015	Chopped
M	29 Jun, 2015	Chopped
n	29 Jun, 2015	Chopped
N	29 Jun, 2015	Chopped
o	29 Jun, 2015	Chopped
O	29 Jun, 2015	Chopped
p	29 Jun, 2015	Chopped
P	29 Jun, 2015	Chopped
q	29 Jun, 2015	Chopped
Q	29 Jun, 2015	Chopped
r	29 Jun, 2015	Chopped
R	29 Jun, 2015	Chopped
s	29 Jun, 2015	Chopped
S	29 Jun, 2015	Chopped
t	29 Jun, 2015	Chopped
T	29 Jun, 2015	Chopped
u	29 Jun, 2015	Chopped
U	29 Jun, 2015	Chopped
v	29 Jun, 2015	Chopped
V	29 Jun, 2015	Chopped
w	29 Jun, 2015	Chopped
W	29 Jun, 2015	Chopped
x	29 Jun, 2015	Chopped
X	29 Jun, 2015	Chopped
y	29 Jun, 2015	Chopped
Y	29 Jun, 2015	Chopped
z	29 Jun, 2015	Chopped
Z	29 Jun, 2015	Chopped

CATH Domains (56)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r67000	10 Jul, 2015	3.60.20.10	Assigned
4r67100	10 Jul, 2015	3.60.20.10	Assigned
4r67200	10 Jul, 2015	3.60.20.10	Assigned
4r67300	10 Jul, 2015	3.60.20.10	Assigned
4r67a00	10 Jul, 2015	3.60.20.10	Assigned
4r67A00	10 Jul, 2015	3.60.20.10	Assigned
4r67b00	10 Jul, 2015	3.60.20.10	Assigned
4r67B00	10 Jul, 2015	3.60.20.10	Assigned
4r67c00	10 Jul, 2015	3.60.20.10	Assigned
4r67C00	10 Jul, 2015	3.60.20.10	Assigned
4r67d00	10 Jul, 2015	3.60.20.10	Assigned
4r67D00	10 Jul, 2015	3.60.20.10	Assigned
4r67e00	10 Jul, 2015	3.60.20.10	Assigned
4r67E00	10 Jul, 2015	3.60.20.10	Assigned
4r67f00	10 Jul, 2015	3.60.20.10	Assigned
4r67F00	10 Jul, 2015	3.60.20.10	Assigned
4r67g00	10 Jul, 2015	3.60.20.10	Assigned
4r67G00	10 Jul, 2015	3.60.20.10	Assigned
4r67h00	10 Jul, 2015	3.60.20.10	Assigned
4r67H00	10 Jul, 2015	3.60.20.10	Assigned
4r67i00	10 Jul, 2015	3.60.20.10	Assigned
4r67I00	10 Jul, 2015	3.60.20.10	Assigned
4r67j00	10 Jul, 2015	3.60.20.10	Assigned
4r67J00	10 Jul, 2015	3.60.20.10	Assigned
4r67k00	10 Jul, 2015	3.60.20.10	Assigned
4r67K00	10 Jul, 2015	3.60.20.10	Assigned
4r67l00	10 Jul, 2015	3.60.20.10	Assigned
4r67L00	10 Jul, 2015	3.60.20.10	Assigned
4r67m00	10 Jul, 2015	3.60.20.10	Assigned
4r67M00	10 Jul, 2015	3.60.20.10	Assigned
4r67n00	10 Jul, 2015	3.60.20.10	Assigned
4r67N00	10 Jul, 2015	3.60.20.10	Assigned
4r67o00	10 Jul, 2015	3.60.20.10	Assigned
4r67O00	10 Jul, 2015	3.60.20.10	Assigned
4r67p00	10 Jul, 2015	3.60.20.10	Assigned
4r67P00	10 Jul, 2015	3.60.20.10	Assigned
4r67q00	10 Jul, 2015	3.60.20.10	Assigned
4r67Q00	10 Jul, 2015	3.60.20.10	Assigned
4r67r00	10 Jul, 2015	3.60.20.10	Assigned
4r67R00	10 Jul, 2015	3.60.20.10	Assigned
4r67s00	10 Jul, 2015	3.60.20.10	Assigned
4r67S00	10 Jul, 2015	3.60.20.10	Assigned
4r67t00	10 Jul, 2015	3.60.20.10	Assigned
4r67T00	10 Jul, 2015	3.60.20.10	Assigned
4r67u00	10 Jul, 2015	3.60.20.10	Assigned
4r67U00	10 Jul, 2015	3.60.20.10	Assigned
4r67v00	10 Jul, 2015	3.60.20.10	Assigned
4r67V00	10 Jul, 2015	3.60.20.10	Assigned
4r67w00	10 Jul, 2015	3.60.20.10	Assigned
4r67W00	10 Jul, 2015	3.60.20.10	Assigned
4r67x00	10 Jul, 2015	3.60.20.10	Assigned
4r67X00	10 Jul, 2015	3.60.20.10	Assigned
4r67y00	10 Jul, 2015	3.60.20.10	Assigned
4r67Y00	10 Jul, 2015	3.60.20.10	Assigned
4r67z00	10 Jul, 2015	3.60.20.10	Assigned
4r67Z00	10 Jul, 2015	3.60.20.10	Assigned

UniProtKB Entries (56)

Accession	Gene ID	Taxon	Description
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1