PDB 4qoc

PDB Information

PDB4QOC
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Wang, Y., Zhu, J., Liu, J.J., Chen, X., Mihalic, J., Deignan, J., Yu, M., Sun, D., Kayser, F., McGee, L.R., Lo, M.C., Chen, A., Zhou, J., Ye, Q., Huang, X., Long, A.M., Yakowec, P., Oliner, J.D., Olson, S.H., Medina, J.C.
Bioorg.Med.Chem.Lett.
HeaderLigase/Ligase Inhibitor
Released2014-06-19
Resolution1.700
CATH Insert Date28 Jun, 2015

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
E 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
I 29 Jun, 2015 Chopped
K 29 Jun, 2015 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4qocA00 20 Mar, 2016 1.10.245.10 Assigned
4qocC00 20 Mar, 2016 1.10.245.10 Assigned
4qocE00 20 Mar, 2016 1.10.245.10 Assigned
4qocG00 20 Mar, 2016 1.10.245.10 Assigned
4qocI00 20 Mar, 2016 1.10.245.10 Assigned
4qocK00 20 Mar, 2016 1.10.245.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
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