PDB 4qls

PDB Links
Overview

PDB Information

PDB	4QLS
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes De Bruin, G., Huber, E.M., Xin, B.T., Van Rooden, E.J., Al-Ayed, K., Kim, K.B., Kisselev, A.F., Driessen, C., Van der Stelt, M., Van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-06-13
Resolution	2.800
CATH Insert Date	10 Aug, 2014

PDB Images (57)

4qls

PDB 4qls

4qlsa

PDB Chain 4qlsa

4qlsA

PDB Chain 4qlsA

4qlsb

PDB Chain 4qlsb

4qlsB

PDB Chain 4qlsB

4qlsC

PDB Chain 4qlsC

4qlsD

PDB Chain 4qlsD

4qlsE

PDB Chain 4qlsE

4qlsF

PDB Chain 4qlsF

4qlsG

PDB Chain 4qlsG

4qlsH

PDB Chain 4qlsH

4qlsI

PDB Chain 4qlsI

4qlsJ

PDB Chain 4qlsJ

4qlsK

PDB Chain 4qlsK

4qlsL

PDB Chain 4qlsL

4qlsM

PDB Chain 4qlsM

4qlsN

PDB Chain 4qlsN

4qlsO

PDB Chain 4qlsO

4qlsP

PDB Chain 4qlsP

4qlsQ

PDB Chain 4qlsQ

4qlsR

PDB Chain 4qlsR

4qlsS

PDB Chain 4qlsS

4qlsT

PDB Chain 4qlsT

4qlsU

PDB Chain 4qlsU

4qlsV

PDB Chain 4qlsV

4qlsW

PDB Chain 4qlsW

4qlsX

PDB Chain 4qlsX

4qlsY

PDB Chain 4qlsY

4qlsZ

PDB Chain 4qlsZ

4qlsa00

CATH Domain 4qlsa00

4qlsA00

CATH Domain 4qlsA00

4qlsb00

CATH Domain 4qlsb00

4qlsB00

CATH Domain 4qlsB00

4qlsC00

CATH Domain 4qlsC00

4qlsD00

CATH Domain 4qlsD00

4qlsE00

CATH Domain 4qlsE00

4qlsF00

CATH Domain 4qlsF00

4qlsG00

CATH Domain 4qlsG00

4qlsH00

CATH Domain 4qlsH00

4qlsI00

CATH Domain 4qlsI00

4qlsJ00

CATH Domain 4qlsJ00

4qlsK00

CATH Domain 4qlsK00

4qlsL00

CATH Domain 4qlsL00

4qlsM00

CATH Domain 4qlsM00

4qlsN00

CATH Domain 4qlsN00

4qlsO00

CATH Domain 4qlsO00

4qlsP00

CATH Domain 4qlsP00

4qlsQ00

CATH Domain 4qlsQ00

4qlsR00

CATH Domain 4qlsR00

4qlsS00

CATH Domain 4qlsS00

4qlsT00

CATH Domain 4qlsT00

4qlsU00

CATH Domain 4qlsU00

4qlsV00

CATH Domain 4qlsV00

4qlsW00

CATH Domain 4qlsW00

4qlsX00

CATH Domain 4qlsX00

4qlsY00

CATH Domain 4qlsY00

4qlsZ00

CATH Domain 4qlsZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	11 Aug, 2014	Chopped
A	11 Aug, 2014	Chopped
b	11 Aug, 2014	Chopped
B	11 Aug, 2014	Chopped
C	11 Aug, 2014	Chopped
D	11 Aug, 2014	Chopped
E	11 Aug, 2014	Chopped
F	11 Aug, 2014	Chopped
G	11 Aug, 2014	Chopped
H	11 Aug, 2014	Chopped
I	11 Aug, 2014	Chopped
J	11 Aug, 2014	Chopped
K	11 Aug, 2014	Chopped
L	11 Aug, 2014	Chopped
M	11 Aug, 2014	Chopped
N	11 Aug, 2014	Chopped
O	11 Aug, 2014	Chopped
P	11 Aug, 2014	Chopped
Q	11 Aug, 2014	Chopped
R	11 Aug, 2014	Chopped
S	11 Aug, 2014	Chopped
T	11 Aug, 2014	Chopped
U	11 Aug, 2014	Chopped
V	11 Aug, 2014	Chopped
W	11 Aug, 2014	Chopped
X	11 Aug, 2014	Chopped
Y	11 Aug, 2014	Chopped
Z	11 Aug, 2014	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4qlsa00	20 Aug, 2014	3.60.20.10	Assigned
4qlsA00	20 Aug, 2014	3.60.20.10	Assigned
4qlsb00	20 Aug, 2014	3.60.20.10	Assigned
4qlsB00	20 Aug, 2014	3.60.20.10	Assigned
4qlsC00	20 Aug, 2014	3.60.20.10	Assigned
4qlsD00	20 Aug, 2014	3.60.20.10	Assigned
4qlsE00	20 Aug, 2014	3.60.20.10	Assigned
4qlsF00	20 Aug, 2014	3.60.20.10	Assigned
4qlsG00	20 Aug, 2014	3.60.20.10	Assigned
4qlsH00	20 Aug, 2014	3.60.20.10	Assigned
4qlsI00	20 Aug, 2014	3.60.20.10	Assigned
4qlsJ00	20 Aug, 2014	3.60.20.10	Assigned
4qlsK00	20 Aug, 2014	3.60.20.10	Assigned
4qlsL00	20 Aug, 2014	3.60.20.10	Assigned
4qlsM00	20 Aug, 2014	3.60.20.10	Assigned
4qlsN00	20 Aug, 2014	3.60.20.10	Assigned
4qlsO00	20 Aug, 2014	3.60.20.10	Assigned
4qlsP00	20 Aug, 2014	3.60.20.10	Assigned
4qlsQ00	20 Aug, 2014	3.60.20.10	Assigned
4qlsR00	20 Aug, 2014	3.60.20.10	Assigned
4qlsS00	20 Aug, 2014	3.60.20.10	Assigned
4qlsT00	20 Aug, 2014	3.60.20.10	Assigned
4qlsU00	20 Aug, 2014	3.60.20.10	Assigned
4qlsV00	20 Aug, 2014	3.60.20.10	Assigned
4qlsW00	20 Aug, 2014	3.60.20.10	Assigned
4qlsX00	20 Aug, 2014	3.60.20.10	Assigned
4qlsY00	20 Aug, 2014	3.60.20.10	Assigned
4qlsZ00	20 Aug, 2014	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3