PDB Information

PDB4PXM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Fanning, S.W., Mayne, C.G., Dharmarajan, V., Carlson, K.E., Martin, T.A., Novick, S.J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B.S., Tajkhorshid, E., Griffin, P.R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J.A., Greene, G.L.
Elife
HeaderHormone/Peptide
Released2014-03-24
Resolution1.900
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Rejected
D 29 Jun, 2015 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4pxmA00 09 Jul, 2015 1.10.565.10 Assigned
4pxmB00 09 Jul, 2015 1.10.565.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
Q15596 NCOA2_HUMAN Homo sapiens Nuclear receptor coactivator 2
Q15596 NCOA2_HUMAN Homo sapiens Nuclear receptor coactivator 2
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor