PDB 4pxm

PDB Links
Overview

PDB Information

PDB	4PXM
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. Fanning, S.W., Mayne, C.G., Dharmarajan, V., Carlson, K.E., Martin, T.A., Novick, S.J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B.S., Tajkhorshid, E., Griffin, P.R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J.A., Greene, G.L. Elife
Header	Hormone/Peptide
Released	2014-03-24
Resolution	1.900
CATH Insert Date	28 Jun, 2015

PDB Images (7)

Image of CATH 4pxm

4pxm

PDB 4pxm

Image of CATH 4pxmA

4pxmA

PDB Chain 4pxmA

Image of CATH 4pxmB

4pxmB

PDB Chain 4pxmB

Image of CATH 4pxmC

4pxmC

PDB Chain 4pxmC

Image of CATH 4pxmD

4pxmD

PDB Chain 4pxmD

Image of CATH 4pxmA00

4pxmA00

CATH Domain 4pxmA00

Image of CATH 4pxmB00

4pxmB00

CATH Domain 4pxmB00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped
C	29 Jun, 2015	Rejected
D	29 Jun, 2015	Rejected

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4pxmA00	09 Jul, 2015	1.10.565.10	Assigned
4pxmB00	09 Jul, 2015	1.10.565.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q15596	NCOA2_HUMAN	Homo sapiens	Nuclear receptor coactivator 2
P03372	ESR1_HUMAN	Homo sapiens	Estrogen receptor
P03372	ESR1_HUMAN	Homo sapiens	Estrogen receptor
Q15596	NCOA2_HUMAN	Homo sapiens	Nuclear receptor coactivator 2