PDB 4p59

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PDB Links
Overview

PDB Information

PDB	4P59
Method	X-RAY DIFFRACTION
Host Organism	Homo sapiens
Gene Source	Homo sapiens
Primary Citation	An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Garner, A.P., Bialucha, C.U., Sprague, E.R., Garrett, J.T., Sheng, Q., Li, S., Sineshchekova, O., Saxena, P., Sutton, C.R., Chen, D., Chen, Y., Wang, H., Liang, J., Das, R., Mosher, R., Gu, J., Huang, A., Haubst, N., Zehetmeier, C., Haberl, M., Elis, W., Kunz, C., Heidt, A.B., Herlihy, K., Murtie, J., Schuller, A., Arteaga, C.L., Sellers, W.R., Ettenberg, S.A. Cancer Res.
Header	Signaling Protein, Immune System
Released	2014-03-15
Resolution	3.400
CATH Insert Date	20 Apr, 2014

PDB Images (12)

Image of CATH 4p59

4p59

PDB 4p59

Image of CATH 4p59A

4p59A

PDB Chain 4p59A

Image of CATH 4p59H

4p59H

PDB Chain 4p59H

Image of CATH 4p59L

4p59L

PDB Chain 4p59L

Image of CATH 4p59A01

4p59A01

CATH Domain 4p59A01

Image of CATH 4p59A02

4p59A02

CATH Domain 4p59A02

Image of CATH 4p59A03

4p59A03

CATH Domain 4p59A03

Image of CATH 4p59A04

4p59A04

CATH Domain 4p59A04

Image of CATH 4p59H01

4p59H01

CATH Domain 4p59H01

Image of CATH 4p59H02

4p59H02

CATH Domain 4p59H02

Image of CATH 4p59L01

4p59L01

CATH Domain 4p59L01

Image of CATH 4p59L02

4p59L02

CATH Domain 4p59L02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	21 Apr, 2014	Chopped
H	21 Apr, 2014	Chopped
L	21 Apr, 2014	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4p59A01	25 Apr, 2014	3.80.20.20	Assigned
4p59A02	25 Apr, 2014	2.10.220.10	Assigned
4p59A03	25 Apr, 2014	3.80.20.20	Assigned
4p59A04	25 Apr, 2014	2.10.220.10	Assigned
4p59H01	25 Apr, 2014	2.60.40.10	Assigned
4p59H02	25 Apr, 2014	2.60.40.10	Assigned
4p59L01	25 Apr, 2014	2.60.40.10	Assigned
4p59L02	25 Apr, 2014	2.60.40.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P21860	ERBB3_HUMAN	Homo sapiens	Receptor tyrosine-protein kinase erbB-3