PDB Information

PDB4OAS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development.
Sun, D., Li, Z., Rew, Y., Gribble, M., Bartberger, M.D., Beck, H.P., Canon, J., Chen, A., Chen, X., Chow, D., Deignan, J., Duquette, J., Eksterowicz, J., Fisher, B., Fox, B.M., Fu, J., Gonzalez, A.Z., Gonzalez-Lopez De Turiso, F., Houze, J.B., Huang, X., Jiang, M., Jin, L., Kayser, F., Liu, J.J., Lo, M.C., Long, A.M., Lucas, B., McGee, L.R., McIntosh, J., Mihalic, J., Oliner, J.D., Osgood, T., Peterson, M.L., Roveto, P., Saiki, A.Y., Shaffer, P., Toteva, M., Wang, Y., Wang, Y.C., Wortman, S., Yakowec, P., Yan, X., Ye, Q., Yu, D., Yu, M., Zhao, X., Zhou, J., Zhu, J., Olson, S.H., Medina, J.C.
J.Med.Chem.
HeaderLigase/Ligase Inhibitor
Released2014-01-06
Resolution1.700
CATH Insert Date23 Feb, 2014

PDB Images (7)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 24 Feb, 2014 Chopped
C 24 Feb, 2014 Chopped
E 24 Feb, 2014 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4oasA00 07 Mar, 2014 1.10.245.10 Assigned
4oasC00 07 Mar, 2014 1.10.245.10 Assigned
4oasE00 07 Mar, 2014 1.10.245.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2