PDB 4lxb

PDB Information

PDB4LXB
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Schreuder, H., Alet, N., Herault, J.P., Millet, L., Dol, F., Florian, P., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.M.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2013-07-29
Resolution1.610
CATH Insert Date29 Jun, 2014

PDB Images (6)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
H 30 Jun, 2014 Chopped
I 30 Jun, 2014 Rejected
L 30 Jun, 2014 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4lxbH01 02 Jul, 2014 2.40.10.10 Assigned
4lxbH02 02 Jul, 2014 2.40.10.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P00734 THRB_HUMAN Homo sapiens Prothrombin
P00734 THRB_HUMAN Homo sapiens Prothrombin
P01050 HIRV1_HIRME Hirudo medicinalis Hirudin variant-1