PDB Information

PDB4LWU
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceXenopus laevis
Primary Citation
Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Zhang, Z., Ding, Q., Liu, J.J., Zhang, J., Jiang, N., Chu, X.J., Bartkovitz, D., Luk, K.C., Janson, C., Tovar, C., Filipovic, Z.M., Higgins, B., Glenn, K., Packman, K., Vassilev, L.T., Graves, B.
Bioorg.Med.Chem.
HeaderLigase/Ligase Inhibitor
Released2013-07-28
Resolution1.140
CATH Insert Date27 Jul, 2014

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 Jul, 2014 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4lwuA00 03 Aug, 2014 1.10.245.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56273 MDM2_XENLA Xenopus laevis E3 ubiquitin-protein ligase Mdm2