PDB Information

PDB4LVD
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Zheng, X., Bair, K.W., Bauer, P., Baumeister, T., Bowman, K.K., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Feng, Y., Han, B., Ho, Y.C., Kley, N., Li, H., Liang, X., Liederer, B.M., Lin, J., Ly, J., O'Brien, T., Oeh, J., Oh, A., Reynolds, D.J., Sampath, D., Sharma, G., Skelton, N., Smith, C.C., Tremayne, J., Wang, L., Wang, W., Wang, Z., Wu, H., Wu, J., Xiao, Y., Yang, G., Yuen, P.W., Zak, M., Dragovich, P.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-07-26
Resolution1.750
CATH Insert Date06 Oct, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 07 Oct, 2013 Chopped
B 07 Oct, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4lvdA01 10 Oct, 2013 Holding pen
4lvdA02 10 Oct, 2013 3.20.20.70 Assigned
4lvdB01 10 Oct, 2013 Holding pen
4lvdB02 10 Oct, 2013 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase