PDB 4lko

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Overview

PDB Information

PDB	4LKO
Method	X-RAY DIFFRACTION
Host Organism	Komagataella pastoris
Gene Source	Homo sapiens
Primary Citation	Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). Devasthale, P., Wang, Y., Wang, W., Fevig, J., Feng, J., Wang, A., Harrity, T., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Weigelt, C., Sun, L., Levesque, P., Moulin, F., Li, Y.X., Zahler, R., Kirby, M.S., Hamann, L.G. J.Med.Chem.
Header	Hydrolase
Released	2013-07-08
Resolution	2.430
CATH Insert Date	22 Sep, 2013

PDB Images (7)

Image of CATH 4lko

4lko

PDB 4lko

Image of CATH 4lkoA

4lkoA

PDB Chain 4lkoA

Image of CATH 4lkoB

4lkoB

PDB Chain 4lkoB

Image of CATH 4lkoA01

4lkoA01

CATH Domain 4lkoA01

Image of CATH 4lkoA02

4lkoA02

CATH Domain 4lkoA02

Image of CATH 4lkoB01

4lkoB01

CATH Domain 4lkoB01

Image of CATH 4lkoB02

4lkoB02

CATH Domain 4lkoB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	23 Sep, 2013	Chopped
B	23 Sep, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lkoA01	25 Sep, 2013	3.40.50.1820	Assigned
4lkoA02	25 Sep, 2013	2.140.10.30	Assigned
4lkoB01	25 Sep, 2013	3.40.50.1820	Assigned
4lkoB02	25 Sep, 2013	2.140.10.30	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P27487	DPP4_HUMAN	Homo sapiens	Dipeptidyl peptidase 4
P27487	DPP4_HUMAN	Homo sapiens	Dipeptidyl peptidase 4