PDB 4kfp

PDB Information

PDB4KFP
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Dragovich, P.S., Bair, K.W., Baumeister, T., Ho, Y.C., Liederer, B.M., Liu, X., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Skelton, N., Wang, L., Wang, W., Wu, H., Xiao, Y., Yuen, P.W., Zak, M., Zhang, L., Zheng, X.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-04-27
Resolution1.840
CATH Insert Date01 Sep, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2013 Chopped
B 02 Sep, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4kfpA01 04 Sep, 2013 Holding pen
4kfpA02 04 Sep, 2013 3.20.20.70 Assigned
4kfpB01 03 Sep, 2013 Holding pen
4kfpB02 03 Sep, 2013 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase