PDB 4jsu

PDB Links
Overview

PDB Information

PDB	4JSU
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-03-22
Resolution	2.900
CATH Insert Date	07 Jul, 2013

PDB Images (61)

4jsu

PDB 4jsu

4jsua

PDB Chain 4jsua

4jsuA

PDB Chain 4jsuA

4jsub

PDB Chain 4jsub

4jsuB

PDB Chain 4jsuB

4jsuc

PDB Chain 4jsuc

4jsuC

PDB Chain 4jsuC

4jsud

PDB Chain 4jsud

4jsuD

PDB Chain 4jsuD

4jsue

PDB Chain 4jsue

4jsuE

PDB Chain 4jsuE

4jsuf

PDB Chain 4jsuf

4jsuF

PDB Chain 4jsuF

4jsuG

PDB Chain 4jsuG

4jsuH

PDB Chain 4jsuH

4jsuI

PDB Chain 4jsuI

4jsuJ

PDB Chain 4jsuJ

4jsuK

PDB Chain 4jsuK

4jsuL

PDB Chain 4jsuL

4jsuM

PDB Chain 4jsuM

4jsuN

PDB Chain 4jsuN

4jsuO

PDB Chain 4jsuO

4jsuP

PDB Chain 4jsuP

4jsuQ

PDB Chain 4jsuQ

4jsuR

PDB Chain 4jsuR

4jsuS

PDB Chain 4jsuS

4jsuT

PDB Chain 4jsuT

4jsuU

PDB Chain 4jsuU

4jsuV

PDB Chain 4jsuV

4jsuW

PDB Chain 4jsuW

4jsuX

PDB Chain 4jsuX

4jsuY

PDB Chain 4jsuY

4jsuZ

PDB Chain 4jsuZ

4jsua00

CATH Domain 4jsua00

4jsuA00

CATH Domain 4jsuA00

4jsub00

CATH Domain 4jsub00

4jsuB00

CATH Domain 4jsuB00

4jsuC00

CATH Domain 4jsuC00

4jsuD00

CATH Domain 4jsuD00

4jsuE00

CATH Domain 4jsuE00

4jsuF00

CATH Domain 4jsuF00

4jsuG00

CATH Domain 4jsuG00

4jsuH00

CATH Domain 4jsuH00

4jsuI00

CATH Domain 4jsuI00

4jsuJ00

CATH Domain 4jsuJ00

4jsuK00

CATH Domain 4jsuK00

4jsuL00

CATH Domain 4jsuL00

4jsuM00

CATH Domain 4jsuM00

4jsuN00

CATH Domain 4jsuN00

4jsuO00

CATH Domain 4jsuO00

4jsuP00

CATH Domain 4jsuP00

4jsuQ00

CATH Domain 4jsuQ00

4jsuR00

CATH Domain 4jsuR00

4jsuS00

CATH Domain 4jsuS00

4jsuT00

CATH Domain 4jsuT00

4jsuU00

CATH Domain 4jsuU00

4jsuV00

CATH Domain 4jsuV00

4jsuW00

CATH Domain 4jsuW00

4jsuX00

CATH Domain 4jsuX00

4jsuY00

CATH Domain 4jsuY00

4jsuZ00

CATH Domain 4jsuZ00

PDB Prints

PDB Chains (32)

Chain ID	Date inserted into CATH	CATH Status
a	08 Jul, 2013	Chopped
A	08 Jul, 2013	Chopped
b	08 Jul, 2013	Chopped
B	08 Jul, 2013	Chopped
c	08 Jul, 2013	Rejected
C	08 Jul, 2013	Chopped
d	08 Jul, 2013	Rejected
D	08 Jul, 2013	Chopped
e	08 Jul, 2013	Rejected
E	08 Jul, 2013	Chopped
f	08 Jul, 2013	Rejected
F	08 Jul, 2013	Chopped
G	08 Jul, 2013	Chopped
H	08 Jul, 2013	Chopped
I	08 Jul, 2013	Chopped
J	08 Jul, 2013	Chopped
K	08 Jul, 2013	Chopped
L	08 Jul, 2013	Chopped
M	08 Jul, 2013	Chopped
N	08 Jul, 2013	Chopped
O	08 Jul, 2013	Chopped
P	08 Jul, 2013	Chopped
Q	08 Jul, 2013	Chopped
R	08 Jul, 2013	Chopped
S	08 Jul, 2013	Chopped
T	08 Jul, 2013	Chopped
U	08 Jul, 2013	Chopped
V	08 Jul, 2013	Chopped
W	08 Jul, 2013	Chopped
X	08 Jul, 2013	Chopped
Y	08 Jul, 2013	Chopped
Z	08 Jul, 2013	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4jsua00	09 Aug, 2013	3.60.20.10	Assigned
4jsuA00	09 Aug, 2013	3.60.20.10	Assigned
4jsub00	09 Aug, 2013	3.60.20.10	Assigned
4jsuB00	09 Aug, 2013	3.60.20.10	Assigned
4jsuC00	09 Aug, 2013	3.60.20.10	Assigned
4jsuD00	09 Aug, 2013	3.60.20.10	Assigned
4jsuE00	09 Aug, 2013	3.60.20.10	Assigned
4jsuF00	09 Aug, 2013	3.60.20.10	Assigned
4jsuG00	09 Aug, 2013	3.60.20.10	Assigned
4jsuH00	09 Aug, 2013	3.60.20.10	Assigned
4jsuI00	09 Aug, 2013	3.60.20.10	Assigned
4jsuJ00	09 Aug, 2013	3.60.20.10	Assigned
4jsuK00	09 Aug, 2013	3.60.20.10	Assigned
4jsuL00	09 Aug, 2013	3.60.20.10	Assigned
4jsuM00	09 Aug, 2013	3.60.20.10	Assigned
4jsuN00	09 Aug, 2013	3.60.20.10	Assigned
4jsuO00	09 Aug, 2013	3.60.20.10	Assigned
4jsuP00	09 Aug, 2013	3.60.20.10	Assigned
4jsuQ00	09 Aug, 2013	3.60.20.10	Assigned
4jsuR00	09 Aug, 2013	3.60.20.10	Assigned
4jsuS00	09 Aug, 2013	3.60.20.10	Assigned
4jsuT00	09 Aug, 2013	3.60.20.10	Assigned
4jsuU00	09 Aug, 2013	3.60.20.10	Assigned
4jsuV00	09 Aug, 2013	3.60.20.10	Assigned
4jsuW00	09 Aug, 2013	3.60.20.10	Assigned
4jsuX00	09 Aug, 2013	3.60.20.10	Assigned
4jsuY00	09 Aug, 2013	3.60.20.10	Assigned
4jsuZ00	09 Aug, 2013	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5