PDB Information

Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Furet, P., Guagnano, V., Fairhurst, R.A., Imbach-Weese, P., Bruce, I., Knapp, M., Fritsch, C., Blasco, F., Blanz, J., Aichholz, R., Hamon, J., Fabbro, D., Caravatti, G.
HeaderTransferase/Transferase Inhibitor
CATH Insert Date06 Apr, 2014

PDB Images (10)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 07 Apr, 2014 Chopped
B 07 Apr, 2014 Chopped

CATH Domains (7)

Domain ID Date inserted into CATH Superfamily CATH Status
4jpsA01 17 Apr, 2014 Assigned
4jpsA02 17 Apr, 2014 Assigned
4jpsA03 17 Apr, 2014 Assigned
4jpsA04 17 Apr, 2014 3.30.1010.10 Assigned
4jpsA05 17 Apr, 2014 1.10.1070.11 Assigned
4jpsB01 14 Nov, 2017 Cathedral cath submit
4jpsB02 14 Nov, 2017 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P42336 PK3CA_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
P27986 P85A_HUMAN Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha