PDB 4jps

PDB Links
Overview

PDB Information

PDB	4JPS
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Furet, P., Guagnano, V., Fairhurst, R.A., Imbach-Weese, P., Bruce, I., Knapp, M., Fritsch, C., Blasco, F., Blanz, J., Aichholz, R., Hamon, J., Fabbro, D., Caravatti, G. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2013-03-19
Resolution	2.200
CATH Insert Date	06 Apr, 2014

PDB Images (10)

Image of CATH 4jps

4jps

PDB 4jps

Image of CATH 4jpsA

4jpsA

PDB Chain 4jpsA

Image of CATH 4jpsB

4jpsB

PDB Chain 4jpsB

Image of CATH 4jpsA01

4jpsA01

CATH Domain 4jpsA01

Image of CATH 4jpsA02

4jpsA02

CATH Domain 4jpsA02

Image of CATH 4jpsA03

4jpsA03

CATH Domain 4jpsA03

Image of CATH 4jpsA04

4jpsA04

CATH Domain 4jpsA04

Image of CATH 4jpsA05

4jpsA05

CATH Domain 4jpsA05

Image of CATH 4jpsB01

4jpsB01

CATH Domain 4jpsB01

Image of CATH 4jpsB02

4jpsB02

CATH Domain 4jpsB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	07 Apr, 2014	Chopped
B	07 Apr, 2014	Chopped

CATH Domains (7)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4jpsA01	17 Apr, 2014	3.10.20.770	Assigned
4jpsA02	17 Apr, 2014	2.60.40.150	Assigned
4jpsA03	17 Apr, 2014	1.25.40.70	Assigned
4jpsA04	17 Apr, 2014	3.30.1010.10	Assigned
4jpsA05	17 Apr, 2014	1.10.1070.11	Assigned
4jpsB01	14 Nov, 2017		Cathedral cath submit
4jpsB02	14 Nov, 2017	1.10.287.1490	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P27986	P85A_HUMAN	Homo sapiens	Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336	PK3CA_HUMAN	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform