Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Northrup, A.B., Katcher, M.H., Altman, M.D., Chenard, M., Daniels, M.H., Deshmukh, S.V., Falcone, D., Guerin, D.J., Hatch, H., Li, C., Lu, W., Lutterbach, B., Allison, T.J., Patel, S.B., Reilly, J.F., Reutershan, M., Rickert, K.W., Rosenstein, C., Soisson, S.M., Szewczak, A.A., Walker, D., Wilson, K., Young, J.R., Pan, B.S., Dinsmore, C.J.
J.Med.Chem.