PDB 4isk
PDB Information
| PDB | 4ISK |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Escherichia coli |
| Primary Citation | Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells.
J.Med.Chem.
|
| Header | Transferase/Transferase Inhibitor |
| Released | 2013-01-16 |
| Resolution | 1.750 |
| CATH Insert Date | 05 Jan, 2014 |
PDB Images (17)
4isk
PDB 4isk
4iskA
PDB Chain 4iskA
4iskB
PDB Chain 4iskB
4iskC
PDB Chain 4iskC
4iskD
PDB Chain 4iskD
4iskE
PDB Chain 4iskE
4iskF
PDB Chain 4iskF
4iskG
PDB Chain 4iskG
4iskH
PDB Chain 4iskH
4iskA00
CATH Domain 4iskA00
4iskB00
CATH Domain 4iskB00
4iskC00
CATH Domain 4iskC00
4iskD00
CATH Domain 4iskD00
4iskE00
CATH Domain 4iskE00
4iskF00
CATH Domain 4iskF00
4iskG00
CATH Domain 4iskG00
4iskH00
CATH Domain 4iskH00
PDB Prints
PDB Chains (8)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 06 Jan, 2014 | Chopped |
| B | 06 Jan, 2014 | Chopped |
| C | 06 Jan, 2014 | Chopped |
| D | 06 Jan, 2014 | Chopped |
| E | 06 Jan, 2014 | Chopped |
| F | 06 Jan, 2014 | Chopped |
| G | 06 Jan, 2014 | Chopped |
| H | 06 Jan, 2014 | Chopped |
CATH Domains (8)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4iskA00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskB00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskC00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskD00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskE00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskF00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskG00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
| 4iskH00 | 09 Jan, 2014 | 3.30.572.10 | Assigned |
UniProtKB Entries (8)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
| P0A884 | TYSY_ECOLI | Escherichia coli K-12 | Thymidylate synthase |
