PDB Information

PDB4HEG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHuman immunodeficiency virus type 1
Primary Citation
Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.
Zhang, H., Wang, Y.F., Shen, C.H., Agniswamy, J., Rao, K.V., Xu, C.X., Ghosh, A.K., Harrison, R.W., Weber, I.T.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-10-03
Resolution1.460
CATH Insert Date01 Sep, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2013 Chopped
B 02 Sep, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4hegA00 10 Sep, 2013 2.40.70.10 Assigned
4hegB00 10 Sep, 2013 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P03367 POL_HV1BR Human immunodeficiency virus type 1 (BRU ISOLATE) Gag-Pol polyprotein
P03367 POL_HV1BR Human immunodeficiency virus type 1 (BRU ISOLATE) Gag-Pol polyprotein