PDB Information

PDB4EZ5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Cho, Y.S., Angove, H., Brain, C., Chen, C.H., Cheng, H., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D.J., Feltell, R., Giraldes, J., Hiscock, S.D., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., McMenamin, R., Mortenson, P.N., Benning, R., O'Reilly, M., Rees, D.C., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A.J., Wrona, W., Xu, M., Yang, F., Howard, S.
ACS Med Chem Lett
HeaderTransferase/Transferase Inhibitor
Released2012-05-02
Resolution2.700
CATH Insert Date28 Mar, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4ez5A01 10 Apr, 2013 3.30.200.20 Assigned
4ez5A02 10 Apr, 2013 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q00534 CDK6_HUMAN Homo sapiens Cyclin-dependent kinase 6