PDB Information

Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
Dossetter, A.G., Beeley, H., Bowyer, J., Cook, C.R., Crawford, J.J., Finlayson, J.E., Heron, N.M., Heyes, C., Highton, A.J., Hudson, J.A., Jestel, A., Kenny, P.W., Krapp, S., Martin, S., MacFaul, P.A., McGuire, T.M., Gutierrez, P.M., Morley, A.D., Morris, J.J., Page, K.M., Ribeiro, L.R., Sawney, H., Steinbacher, S., Smith, C., Vickers, M.
HeaderHydrolase/Hydrolase Inhibitor
CATH Insert Date04 Nov, 2012

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4dmyA00 10 Nov, 2012 Assigned
4dmyB00 10 Nov, 2012 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43235 CATK_HUMAN Homo sapiens Cathepsin K
P43235 CATK_HUMAN Homo sapiens Cathepsin K