PDB Information

PDB4CMU
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
Johnson, T.W., Richardson, P.F., Bailey, S., Brooun, A., Burke, B.J., Collins, M.R., Cui, J.J., Deal, J.G., Deng, Y.L., Dinh, D.M., Engstrom, L.D., He, M., Hoffman, J.E., Hoffman, R.L., Huang, Q., Kath, J., Kania, R.S., Lam, H., Lam, J.L., Le, P.T., Lingardo, L., Liu, W., Mctigue, M.A., Palmer, C.L., Sach, N.W., Smeal, T., Smith, G.L., Stewart, A.E., Timofeevski, S.L., Zhu, H., Zhu, J., Zou, H.Y., Edwards, M.P.
J.Med.Chem.
HeaderTransferase
Released2014-01-17
Resolution1.800
CATH Insert Date01 Jun, 2014

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 02 Jun, 2014 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4cmuA01 03 Jun, 2014 3.30.200.20 Assigned
4cmuA02 03 Jun, 2014 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q9UM73 ALK_HUMAN Homo sapiens ALK tyrosine kinase receptor