PDB 4bfr

PDB Information

PDB4BFR
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceMUS MUSCULUS
Primary Citation
Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
Certal, V., Carry, J.B., Halley, F., Virone-Oddos, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Karlsson, A., Charrier, V., Delorme, C., Rak, A., Abecassis, P., Amara, C., Vincent, L., Bonnevaux, H., Nicolas, J., Mathieu, M., Bertrand, T., Marquette, J., Michot, N., Benard, T., Perrin, M., Lemaitre, O., Guerif, S., Perron, S., Monget, S., Gruss-Leleu, F., Doerflinger, G., Guizani, H., Brollo, M., Delbarre, L., Bertin, L., Richepin, P., Loyau, V., Garcia-Echeverria, C., Lengauer, C., Schio, L.
J.Med.Chem.
HeaderTransferase
Released2013-03-22
Resolution2.800
CATH Insert Date02 Feb, 2014

PDB Images (13)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 03 Feb, 2014 Chopped
B 03 Feb, 2014 Chopped

CATH Domains (10)

Domain ID Date inserted into CATH Superfamily CATH Status
4bfrA01 07 Mar, 2014 3.10.20.90 Assigned
4bfrA02 07 Mar, 2014 2.60.40.150 Assigned
4bfrA03 07 Mar, 2014 1.25.40.70 Assigned
4bfrA04 07 Mar, 2014 3.30.1010.10 Assigned
4bfrA05 07 Mar, 2014 1.10.1070.11 Assigned
4bfrB01 07 Mar, 2014 1.25.40.70 Assigned
4bfrB02 07 Mar, 2014 3.10.20.90 Assigned
4bfrB03 07 Mar, 2014 2.60.40.150 Assigned
4bfrB04 07 Mar, 2014 3.30.1010.10 Assigned
4bfrB05 07 Mar, 2014 1.10.1070.11 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q8BTI9 PK3CB_MOUSE Mus musculus Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Q8BTI9 PK3CB_MOUSE Mus musculus Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform