PDB 4b95

PDB Information

PDB4B95
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1Alpha
Buckley, D.L., Gustafson, J.L., Van Molle, I., Roth, A.G., Tae, H.S., Gareiss, P.C., Jorgensen, W.L., Ciulli, A., Crews, C.M.
Angew.Chem.Int.Ed.Engl.
HeaderTranscription
Released2012-08-31
Resolution2.800
CATH Insert Date04 Nov, 2012

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped
C 05 Nov, 2012 Chopped
D 05 Nov, 2012 Chopped
E 05 Nov, 2012 Chopped
F 05 Nov, 2012 Chopped
G 05 Nov, 2012 Chopped
H 05 Nov, 2012 Chopped
I 05 Nov, 2012 Chopped
J 05 Nov, 2012 Chopped
K 05 Nov, 2012 Chopped
L 05 Nov, 2012 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4b95A00 10 Nov, 2012 3.10.20.90 Assigned
4b95B00 10 Nov, 2012 3.30.710.10 Assigned
4b95C01 10 Nov, 2012 2.60.40.780 Assigned
4b95C02 10 Nov, 2012 1.10.750.10 Assigned
4b95D00 10 Nov, 2012 3.10.20.90 Assigned
4b95E00 10 Nov, 2012 3.30.710.10 Assigned
4b95F01 10 Nov, 2012 2.60.40.780 Assigned
4b95F02 10 Nov, 2012 1.10.750.10 Assigned
4b95G00 10 Nov, 2012 3.10.20.90 Assigned
4b95H00 10 Nov, 2012 3.30.710.10 Assigned
4b95I01 10 Nov, 2012 2.60.40.780 Assigned
4b95I02 10 Nov, 2012 1.10.750.10 Assigned
4b95J00 10 Nov, 2012 3.10.20.90 Assigned
4b95K00 10 Nov, 2012 3.30.710.10 Assigned
4b95L01 10 Nov, 2012 2.60.40.780 Assigned
4b95L02 10 Nov, 2012 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor