Optimization of Imidazo[4,5-B]Pyridine-Based Kinase Inhibitors: Identification of a Dual Flt3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia.
Bavetsias, V., Crumpler, S., Sun, C., Avery, S., Atrash, B., Faisal, A., Moore, A.S., Kosmopoulou, M., Brown, N., Sheldrake, P.W., Bush, K., Henley, A., Box, G., Valenti, M., De Haven Brandon, A., Raynaud, F.I., Workman, P., Eccles, S.A., Bayliss, R., Linardopoulos, S., Blagg, J.
J.Med.Chem.