PDB 4ap7

PDB Information

PDB4AP7
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (C-met) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-Ylmethyl)-1H-[1,2, 3]Triazolo[4,5-B]Pyrazin-6-Yl)-1H-Pyrazol-1-Yl)Ethanol (Pf-04217903) for the Treatment of Cancer.
Cui, J.J., Mctigue, M., Nambu, M., Tran-Dube, M., Pairish, M., Shen, H., Jia, L., Cheng, H., Hoffman, J., Le, P., Jalaie, M., Goetz, G.H., Ryan, K., Grodsky, N., Deng, Y., Parker, M., Timofeevski, S., Murray, B.W., Yamazaki, S., Aguirre, S., Li, Q., Zou, H., Christensen, J.
J.Med.Chem.
HeaderTransferase
Released2012-03-30
Resolution1.800
CATH Insert Date04 Nov, 2012

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4ap7A01 10 Nov, 2012 3.30.200.20 Assigned
4ap7A02 10 Nov, 2012 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P08581 MET_HUMAN Homo sapiens Hepatocyte growth factor receptor